TREATMENT OF PATIENTS WITH GIANT CELL BONE TUMOR IN NORTHERN BRAZIL, IN 2020 AND 2021

Couto Filho, Fernando Brasil do; Yonamine, Eduardo Sadao; Magno, Felipe Guimarães; Favacho-Silva, Ana Beatriz; Brito, Carlos Rafael Alves de; Brito, Thiago Raphael Brasil

doi:10.1590/1413-785220253301e285342

Fernando Brasil do Couto FilhoCorrespondence: Fernando Brasil do Couto Filho. 2000, Centenário Ave., Condomínio Água Cristal, Alameda Beijupirá, n. 16., Bairro Mangueirão, Belém, PA, Brazil. 66640-658. fernandobrasilfilho@gmail.com

critical revision of its intellectual content and final approval

contributed individually and significantly to the development of this article

Hospital Ophir Loyola, Orthopaedic Oncology Department, Belém, PA, Brazil

https://orcid.org/0000-0003-2807-7600

Eduardo Sadao Yonamine

critical revision of its intellectual content and final approval

contributed individually and significantly to the development of this article

Santa Casa de Misericórdia de São Paulo, Orthopaedic Oncology Department, São Paulo, SP, Brazil

https://orcid.org/0000-0001-6924-2647

Felipe Guimarães Magno

contribution to the conception of the word, critical revision of its intellectual content, and final approval

contributed individually and significantly to the development of this article

Hospital Ophir Loyola, Orthopaedic Oncology Department, Belém, PA, Brazil

Santa Casa de Misericórdia de São Paulo, Orthopaedic Oncology Department, São Paulo, SP, Brazil

https://orcid.org/0009-0009-0078-4507

Ana Beatriz Favacho-Silva

contribution to conception, analysis, and interpretation of data for the work

drafting the work and critical revision of its intellectual content

contributed individually and significantly to the development of this article

Hospital Ophir Loyola, Orthopaedic Oncology Department, Belém, PA, Brazil

https://orcid.org/0000-0001-5414-995X

Carlos Rafael Alves de Brito

contribution to conception and analysis of the work, drafting the work

contributed individually and significantly to the development of this article

Hospital Ophir Loyola, Orthopaedic Oncology Department, Belém, PA, Brazil

https://orcid.org/0009-0001-5726-7780

Thiago Raphael Brasil Brito

contribution to conception and analysis of the work, drafting the work

contributed individually and significantly to the development of this article

Hospital Ophir Loyola, Orthopaedic Oncology Department, Belém, PA, Brazil

https://orcid.org/0000-0003-1455-8868

Correspondence: Fernando Brasil do Couto Filho. 2000, Centenário Ave., Condomínio Água Cristal, Alameda Beijupirá, n. 16., Bairro Mangueirão, Belém, PA, Brazil. 66640-658. fernandobrasilfilho@gmail.com

All authors declare no potential conflict of interest related to this article.

The study was conducted at Ophir Loyola Hospital.

Variable	Frequency (n. 19)	Percentage (%)	CI95%
Sex
Male	11	57.89	36.8 - 78.9
Female	8	42.11	21.1 - 63.2
Age (years)
Mean ( sd)	37.32 ( 13.47)		31.0 - 43.8
Median (p25-75%)	39.00 (24.00 - 45.50)		24.0 - 44.0
Age range
< 30 years	6	31.58	10.5 - 52.6
≥ 30 years	13	68.42	47.4 - 89.5
Location
Metropolitan region of Belém	6	31.58	10.5 - 52.6
Other regions of Pará	9	47.37	26.3 - 68.4
Other state	4	21.05	5.3 - 42.1
Patient delay (months)
Mean ( sd)	10.47 ( 13.08)		6.1 - 17.1
Median (p25-75%)	7.00 (4.00 - 12.00)		4.0 - 12.0
Patient delay ≥ 12 months
Yes	6	31.58	10.5 - 52.6
No	13	68.42	47.4 - 89.5
Anatomic location
Proximal femur	1	5.26	0.0 - 15.8
Distal femur	9	47.37	21.2 - 68.4
Proximal tibia	6	31.58	10.5 - 52.6
Calcaneus	1	5.26	0.0 - 15.8
Hand bones	2	10.53	0.0 - 26.3
Campanacci
Stage 1	2	10.53	0.0 - 26.3
Stage 2	3	15.79	0.0 - 31.6
Stage 3	14	73.68	52.5 - 89.5
Pathological fracture
Yes	3	15.79	0.0 - 36.8
No	16	84.21	63.2 - 100.0
Surgery type
Wide resection	14	73.68	52.5 - 89.5
Marginal/Intralesional	3	15.79	0.0 - 31.6
Not performed	2	10.53	0.0 - 26.3
Recurrence
Yes	3	15.79	0.0 - 36.8
No	16	84.21	63.2 - 100.0
Denosumab use
Yes	5	26.32	10.5 - 47.4
No	14	73.68	52.5 - 89.5
Pulmonary metastasis
Yes	0	0.00	0.0 - 0.0
No	19	100.00	100.0 - 100.0

Variable	Stage 1 e 2 (n. 5)	Stage 3 (n. 14)	p-value
Sex
Male	1(20.0%)	10(71.4%)	0.071^a
Female	4(80.0%)	4(28.6%)	0.071^a
Age(years)
Mean( sd)	38.6( 9.6)	36.8( 14.9)	0.830^b
Median(p25-75%)	39.0(39.0-43.0)	36.5(24.0-47.0)	0.830^b
Agerange
<30years	1(20.0%)	5(35.7%)	0.480^a
>30years	4(80.0%)	9(64.9%)	0.480^a
Location
MetropolitanregionofBelém	1(20.0%)	5(35.7%)	0.814^a
OtherregionsofPará	3(60.0%)	6(42.9%)
Otherstate	1(20.0%)	3(21.4%)
Patientdelay
Mean( sd)	14.0( 25.7)	9.2( 5.2)	0.070^b
Median(p25-75%)	3.0(2.0-4.0)	7.5(6.0-12.0)	0.070^b
Patientdelay≥12months
Yes	1(20.0%)	5(35.7%)	0.631^a
No	4(80.0%)	9(64.3%)	0.631^a
Anatomiclocation
Proximalfemur	0(0.0%)	1(7.1%)	0.164^a
Distalfemur	3(60.0%)	6(42.9%)
Proximaltibia	0(0.0%)	6(42.9%)
Calcaneus	1(20.0%)	0(0.0%)
Handbones	1(20.0%)	1(7.1%)
Pathologicalfracture
Yes	0(0.0%)	3(21.4%)	0.530^a
No	5(100.0%)	11(78.6%)	0.530^a
Surgerytype
Wideresection	1(20.0%)	13(92.9%)	0.002^a*
Marginal/Intralesional	3(60.0%)	0(0.0%)
Notperformed	1(20.0%)	1(7.1%)
Recurrence
Yes	0(0.0%)	3(21.4%)	0.530^a
No	5(100.0%)	11(78.6%)	0.530^a
Denosumabuse
Yes	0(0.0%)	5(35.7%)	0.257^a
No	5(100.0%)	9(64.3%)	0.257^a
Pulmonarymetastasis
Yes	0(0.0%)	0(0.0%)	1.000^a
No	5(100.0%)	14(100.0%)	1.000^a

[TFN1] Sd: Standard deviation. P: Percentile. CI: confidence interval.

TREATMENT OF PATIENTS WITH GIANT CELL BONE TUMOR IN NORTHERN BRAZIL, IN 2020 AND 2021

TRATAMENTO DE PACIENTES COM TUMOR ÓSSEO DE CÉLULAS GIGANTES NO NORTE DO BRASIL, EM 2020 E 2021

Abstract